Abstract: The key problem of microbe oil recovery is the quality of germ. According to the reservoir and fluid character of Ze-10 fault of Huabei Oilfield, a compound germ FR 1 was formed with four base germ. The capability of microbe germ’s development, viscosity reducing, pour point depression and paraffin inhibition was evaluated in lab. After field using, the problems of Ze-10 fault, including severe wax precipitation, short period of thermal cleanout, difficulty production run and higher production cut, was solved.