Abstract: Aimed to poor profile-control effect due to severe heterogeneity in most oil fields, Technical Institute of Physics and Chemistry of CAS developed a new agent named “polymer elastic microsphere emulsion”. Three core experiments were conducted with the agent. Artificial short core experiment shows that new agent has good plugging performance and stability in porous media; and artificial long core test indicates a good viscoelasticity and tensility of the agent in porous media, which can be used for deep profile control; heterogeneous short cores test with three-tube in parallel indicates that the new agent can significantly reduce fractional flow through high permeability channel, with good profile control effect and oil displacement efficiency. Finally, different concentration effect on sweep efficiency is also studied. The polymer elastic microsphere emulsion can be recommended as a potential agent for profile control.