Abstract: In the development design for Well Niuye 1, it is required to conduct long-section continuous sealing core drilling. The coring formations are lower Sha-3 and lower Sha-4, and the coring footage is 225 m, so the coring difficulty is great. Through selecting sealing coring tool, coring bit, screening proper coring fluid, and optimizing drilling parameters, the yield of 90.46% is obtained. The success application of continuous sealing core drilling technique on Well Niuye 1 plays an important role in getting aware of the reservoir characteristics and oil saturation of Niuye 1 Zone in Niuzhuang-Liuhu Depression. It supplies reference for conducting continuous sealing core drilling in the same kind of formation.