Abstract: Considering the low success rate of running and pulling the downhole plug in eccentric separate injection well, the original plug is improved in its structure: a pressure relief channel is designed with the main body of the plug to reduce the pulling resistance of the plug, the connection mode of clamping by friction between delivery head and plug is applied to avoid dropping or falling off during running; the angle of the bottom-filter plug is optimized, which leads to more successful running of the plug. Field construction of more than 260 wells of proves that the success rate of running and pulling in eccentric separate injection wells can be significantly improved by use of pressure-relief eccentric plug.