Abstract: In order to solve the problems that it is difficult to load and remove packer during separated injection process and uneven force and creep deformations on rubber tube of packer in setting sealing and well washing process in highly deviated injection wells in Nanpu oilfield. By analyzing and improving the structure of conventional injection packer Y341, adopting the high temperature and high pressure resistant seal components, the improved packer could better meet the work conditions and work requirements of deviated wells and is capable of repeating setting seal. The experiments of laboratory and field showed that the packer could satisfy the demand of high temperature and high pressure injection in highly deviated wells and could realize eccentric quantitative separated injection in extended reach wells with deviation angle between 50 and 70 degree.