Abstract: In order to explore the oil and gas resource at the prospects of central uplift zone in Ferghana basin which is with ultra deep burial depth（6 000-6 800 m）, high bottom-hole temperature, high pressure, high acidic gas content and high salinity, which poses a big challenge to drilling and cementing, and well control safety, and considering the fact that drilling works there before almost did not succeed to reach the target formation at all, The monographic study and field application were carried out on speeded drilling integrated technology, drilling fluid technology in complex stratum, well cementing technology in deep or ultra deep reservoirs, well schematic optimization of “four high and one ultra” wells and well control technology in the year of 2008 and 2009. With the technology, several drilling and completion technical problems in Fergana had been solved, mainly including penetrating, wire line logging, running casing and cementing in the conditions of high temperature（140 ℃）, high pressure（144 MPa） and high density mud（2.42 g/cm3）. The integrated technology was applied in well Jida 3 and Jida 4 drilling, and the well of Jida 4 had been smoothly drilled to the depth of 6 596 m. The advanced drilling and completion integrated technology will support drilling deep and ultra deep well safe at Fergana basin in the future.