Abstract: Due to the small well spacing, large amount of drilled well, and great difficulty of interwell anti-collision drilling sequence optimization, by the method of mass observation and systematic study, the drag direction of whole platform and drilling rigs, the position of target point and wellhead, and the orientation relationship of different wells are systematically studied. Taking the matured 168 cluster well as an example, based on the results calculated by Paradigm, an approach of whole optimized drilling sequence is proposed, and the arrangement of drilling sequence is analyzed. The study shows that optimization of intensive cluster well drilling sequence should be based on the analysis of adverse factors, anti-avoidance control, the characteristics of the reservoir and the distribution of wells, combining with its own characteristics. Then, the calculation software is used during the entire drilling procedure to improve the drilling sequence. At last, the best drilling sequence which not only meet reservoir requirements but also the purpose of drilling is achieved. It supplies an scientific evidence for domestic large scale cluster well drilling program planning.