Abstract: To overcome the stimulation difficulties for horizontal well formations during the later period of development and production, such as complex operation process, high cost, and low efficiency, the experimental research of liquid explosive fracturing in horizontal well layers is carried out. Based on the study on the intralayer exploding technology and the application of the liquid explosives blast experiment in horizontal well layers, the calculation model and method of forming crack system in the process of the liquid explosives blasting in horizontal wells are studied, and the affection of elastic seismic waves of explosion is analyzed. The main parameters calculation and analysis are combined with the field test of the liquid explosive fracturing applied in CZ44-58 horizontal well. Field test proves the safety and reliability of the liquid explosives test on horizontal wells and the operability of the site using. The method provides design reference and guidance for the further development of the liquid explosive fracturing.