Abstract: Multilateral intersection well is the more advanced layout for coal-bed methane at home and abroad. Drilling multilateral well after the successful intersection of horizontal well and vertical well is the common exploitation method. With the development of coal-bed methane, many difficulties appear in the traffic inconvenience area such as hilly and mountainous areas. The difficulties include limited well-site arrangement, multiplied cost of well site road construction, and difficult management in decentralized production, etc. Coal-bed methane exploitation change from vertical well to directional well is studied, and it can largely solve the limited well-site arrangement, decrease the cost of well site road construction, and achieve the centralized management for clustered wells. To some extent, it creates new exploitation domain of coal-bed methane. However, we have no antecedent of horizontal well intersection with directional well to guide. ZY-H4-LS well group adopts lots of technologies like integrative design and integrative construction of multilateral well and directional well, and succeeds in realizing intersection between multilateral horizontal well and directional well. It created national precedent for this kind of construction and offers a new idea for coal-bed methane exploitation.