Abstract: To solve the problems of security risk and reaction speed in traditional thermo-chemical process, study of controllable thermochemistry technology was conducted. The new mediator of MHA was developed by comparing the influences of different catalysts, initial solution concentration, temperature and catalyst concentration to reaction. Results showed that the reaction time to reach peak is no less than 2 hours which can meet the safety performance requirements. The best response concentration is 3 mol/L after adding the same kind of catalyst. It is easier to control the reaction speed if the initial reaction mixture temperature is within 40 ℃. The higher the concentration is, the faster catalyst reaction is. The controllable thermochemistry technology was applied to Well Shu1-38-45, Liaohe Shuguang oil region. Results showed that after measures the average daily liquid production was 2.8 m3 and oil 1.8 m3 compared to average daily liquid production was 1.6 m3 and oil 0.8 m3 before that. The measure effect was significant.