Abstract: Sakhalin-E Block is the first cooperation project between China and Russia in oil and gas exploration. Sino-Russian Joint Operating Company has drilled three exploration wells in the block one after another. The region can be characterized by “three high”, i.e. high daily cost, high inclination angle, and high gas content. Problems of complicated geological conditions, large strata dip, strong abrasion, poor drillability, and serious strata loss are all encountered during operation. Drilling speed are always restricted by the great drilling difficult, shallow operation window, and high risks. To solve the above problems, multiple technological researches are carried out for high quality and high speed drilling in Sakhalin region, as a result six systematic technologies are developed, including the casing optimization, the application of compositing drilling, the bit optimization, the processing of balling, the anti-collapse drilling fluid technology, the organization and management of high quality and high speed drilling. All the technologies are applied to guide field production, enhancing the drilling efficiency, decreasing risks, and proving effective guarantee for speeding up exploration and development.