Abstract: At present, the location of the anti-lopsided wear centralizer used in fields is mainly based on the deviation angle. In fact, lopsided wear may be caused by the change of azimuth angle or by the vertical well section and hold angle section during the working of the bucket rod. In this paper, combined with the roof bolt kinetics model, the lopsided wear technique is used to virtual the lopsided wear point. On this basis, the number and location of the centralizer will be determined, providing effective tool for the design of well centralizer.