Abstract: Based on the nonionic polyether surfactant and its combination with anionic and zwitterionic surfactants,the FRY-II surfactant is developed to deal with the pollution of oil wells with unstable production and insufficient feed flow after being controlled by CaCl2 and CaBr2 solutions during pump detection and workover.In acid medium,the surfactant will develop into acid surfactant to eliminate alkali sensitivity and water sensitivity of the formation.It has been applied to plug removal of oil wells and better economic benefit has been obtained.The new surfactant has better application value.