Abstract: There is abundance oil in jianghan inter-saltnon-sandstone reservoir,but it is difficulty to exploration because of complex lithology and abnormal stress.Analyzed effect of stress to this reservoir,and compared it with sandstone reservoir,showed it has obvious stress sensitivity characters,this seriously effect exploitation of later period,for this kind of reservoir,should inject water at forepart and control production pressure difference, try to keep reservoir pressure close to initial pressure,this will delay decrease of oil output and prolong treating effect of a well.