Abstract: Donghe-1 oilfield is located in Donghe-1 anticline structure south to Kuche county, Xinjiang, is the deepest marine block sandstone reservoir discovered up to now in China, and is one of the main production areas in Tarim Field. Based on the analysis to the geologic features, damage factors and water injection status of water injection wells in Donghe-1 oilfield, this paper analyzes the necessity of acidizing, presents the research results of acidizing fluids system and operation technology, as well as the on-site application ef feet.