Abstract: This paper selects optimally the profile control well by using the uncertainty-expression method to express the five factors such as permeability, water injection profile, water injection performance, pressure fall-off curve, recovery percent of reserves~water cut relationship as the decision factors of well selection when conducting integral profile control in a block. This paper uses the water injection performance to select optimally the type and usage of the water shutoff agent, presents the optimal operation parameters and a whole set of method for predicting the operation effect. This paper also evaluates the development effect of profile control in terms of recovery curve, stimulation effect, improving recoverable reserves, decreasing water cut, etc., and evaluates the operation effect of profile control well in terms of pressure fall-off curve, water injection profile, etc. Therefore, the integral block profile control has been systematized, that is,from well selection decision, water shutoff agent decision, operation design, effect prediction, to effect evaluation. This technology has been used in block Pan2-26 successfully, and obvious effect has been achieved.