Abstract: The waterflood development of ultra-low permeability reservoirs in Ordos is faced with many problems. For example, the support system for conventional separate layer water injection technology is of high cost, artificial operation is complex, qualification rate of separate layer water injection drops fast, and dynamic data of stratification cannot be monitored for the long time. In this paper, the whole-process intelligent monitoring technology for water flooding was developed to solve these problems. This technology is composed of automatic-control bottom hole regulator, integrated surface transmission and control device and remote monitoring system. By virtue of fluid wave code technology and intelligent downhole flow control theory, a series of functions are realized, such as automatic testing and control of downhole flow rate of each layer, long-term testing and storage of dynamic data, remote wireless communication of surface and downhole data, and real-time monitoring of oilfield digitizing system. In 2016, this technology was tested on site at 20 wells in a typical ultra-low permeability block, and its qualification rate of separate layer water injection is 95%. By virtue of intelligent waterflood monitoring technology, water flow is regulated precisely, single layer breakthrough is controlled effectively, unavailable water circulation is reduced, and the dynamic process of oil reservoir development is understood truly. It provides the technological basis for the efficient waterflood development of oil reservoirs.