Abstract: In order to monitor the change laws of physical property parameters in process of formation and decomposition of natural gas hydrate, it is necessary to install various sensor measurement points in reactors. However, the introduction of sensor measurement points influences the flowing situations of fluids in reactors. In order to alleviate the disturbance, the relationship between measurement point dimension and minimum point-to-point spacing was analyzed quantitatively by means of numerical simulation. It is indicated that the seepage field in reactors are affected by the introduction of sensor measurement points. The larger the measurement points are and the shorter the point-to-point spacing is, the more the seepage field is affected. The minimum point-to-point spacing corresponding to the point dimension of 10 mm, 9 mm, 8 mm, 7 mm and 6 mm is 60 mm, 54 mm, 48 mm, 42 mm and 36 mm, respectively. Therefore, the point-to-point spacing shall not be shorter than 6 times the measurement point dimension when sensor measurement points are arranged in reactors. The research results are of instructive significance to the deployment of measurement points in reactors.