Abstract: Monitoring formation pressure and temperature during separate-layer water flooding can provide reliable data for geologic study of relevant formations, but monitoring techniques currently available can not monitor formation pressure and temperature all the way. Based on principles and tool structure of eccentric quantitative water flooding technique and downhole monitoring technique,integration of separate-layer quantitative water flooding and pressure monitoring has been achieved by adopting integration research principles and designs. During the course, a plug with water-flooding and pressure monitoring capacities, water-flooding and pressuremonitoring barrel with testing channels, and special delivery device with valve-bottom supporting assembly have been developed. Lab test results show all the key tools have reliable sealing performance to satisfy demands related to place, recover and replace of waterflooding and pressure-monitoring plugs. Up to now, the technique has been used in 5 wells with a success rate of 100%. Moreover, 100% of pressure and temperature data acquired are qualified, expanding the function of conventional eccentric separate-layer water flooding technique, the newly developed system has bright prospects of application on site.