Abstract: The ultra-deep wells in Keshen Block of Tarim Oilfield have high temperature, high pressure and long perforated sections, so it is very hard for normal fracturing to achieve reservoir reconstruction. Through geologic analysis and reservoir evaluation for target well and in line with the difficulties in fracturing of the target well, a modification idea was presented and implemented on site. It was decided that mixed fracturing method was used with gel fluid fracturing as the main approach and slickwater volumetric fracturing as the auxiliary. Staged fracturing was carried out by cluster perforation and fiber plugging diversion technology, and the fracturing plan was duly adjusted by monitoring the fracture development. Field job successfully realized zonal fracturing in ultra-deep and HTHP wells, and increased the target production from 1.5×104 m3/d to 21×104 m3/d, providing a favorable guiding significance for reservoir reconstruction in similar wells in this block.